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Murfreesboro Back Pain Related to Inflammation Reduced with Melatonin

Inflammation. Disc Degeneration. There is a relationship. Inflammation is the body’s response to damaging stimuli (injury, pathogens, metabolic stress – a disc herniation pushing on a nerve!) as it tries to restore itself to normal before the harm was achieved. Most Chiropractic Clinic is always amazed at what the body can do! Most Chiropractic Clinic sees its Murfreesboro chiropractic care as a partner of the body’s system in healing particularly when spine pain is an issue. Chiropractic care utilizes many tools like spinal manipulation, exercise, and nutrition to take care of the body. Melatonin is one nutritional tool that is showing value in its ability to interrupt the inflammatory process related disc herniation that results in back pain, neck pain and other spine related pain.

DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'

Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are related to intervertebral disc degeneration. (1) IL-1 β in fact promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body regulates itself down to the cellular level via autophagy, the natural process during which the body’s cells clear out damaged (ie, by inflammation) or unneeded parts. In a new study, melatonin boosted autophagy and reduced the degradation of the disc’s extracellular matrix (technically marked by a decline in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The final conclusion was that melatonin prevents intervertebral disc degeneration by promoting autophagy. (3) Wow. Most Chiropractic Clinic is encouraged by this research to see just how well melatonin can work for Murfreesboro back pain related to disc degeneration.

MELATONIN AND ITS HEALING WAYS FOR THE DISC

Disc degeneration is quite a common malady seen at Most Chiropractic Clinic that positive news of melatonin’s benefits are quite exciting. A new study described that melatonin could modify the extracellular matrix of the disc remodeling process initiated by IL-1 β. Additionally, melatonin reduced the inflammatory cell collection and reduced the release of associated inflammatory markers IL-1β, IL-6, and TNF-α. With this new discovery that melatonin disrupted the IL-1B feedback loop, researchers proposed that melatonin may support the healing process of intervertebral discs after damage has already been done. (1) Most Chiropractic Clinic continues following the new research on the role inflammation has in Murfreesboro disc degeneration and melatonin’s role in combatting it.

INFLAMMATION AND MELATONIN

The importance of melatonin in helping to slow or stop painful conditions due to inflammation is increasing. The description of melatonin as a multitasking molecule affecting mood, immunity, and energy among other things is quite apropos. It’s also anti-oxidant, anti-aging, and anti-inflammatory, specifically by blocking the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland secretes melatonin naturally. Melatonin influences the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) activities. (1) Melatonin’s specific influence on inflammation and disc degeneration is most interesting to Most Chiropractic Clinic and our Murfreesboro back pain patients.

CONTACT Most Chiropractic Clinic

Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she describes how The Cox® Technic System of Spinal Pain Management addresses disc degeneration for relief of chronic low back pain in her patient.

Schedule your Murfreesboro chiropractic appointment with Most Chiropractic Clinic today. We can talk about how inflammation affects your back pain and how melatonin may help with the related disc degeneration.

 
Most Chiropractic Clinic shares new findings that melatonin interrupts the inflammatory process in disc degeneration that causes back pain. 
 
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"This information and website content is not intended to diagnose, guarantee results, or recommend specific treatment or activity. It is designed to educate and inform only. Please consult your physician for a thorough examination leading to a diagnosis and well-planned treatment strategy. See more details on the DISCLAIMER page. Content is reviewed by Dr. James M. Cox I."